研究成果 |
1. 揭示了细胞增殖周期G1/S 期的关键驱动激酶Cdk2 对细胞凋亡的促进作用，阐明了哺乳动物细胞精确平衡细胞增殖和细胞死亡的分子机制，是细胞凋亡通路的重要补充。
2. 系统筛选了稀有人参皂苷的人类靶点，为人参抗肿瘤作用提供了依据。
3. 在人参深加工领域取得了重大进展。利用生物转化技术对吉林人参进行深加工，制备了《百年参素》系列人参深加工产品。《百年参素》中高活性稀有人参皂苷群含量达到皂苷总量的60%，这是未经加工吉林人参的500倍。同时，彻底解决了人参“上火、升血压”等副作用，任何体质的人群均可享用、获益。
4. 负责完成了6项国家自然科学基金项目，负责执行7项省部级项目，在Protein Cell, JBC, EMBO Rep等国际重点杂志上发表SCI论文70篇，被引次数达2000余次，授权专利7项。
发表的部分论文 1. Chen Chen, Yu-Shi Wang, En-Ting Zhang, Gang-Ao Li, Wen-Yuan Liu, Yang Li, and Ying-Hua Jin * (20S) Ginsenoside Rh2 exerts its anti‐tumor effect by disrupting the HSP90A‐Cdc37 system in human liver cancer cells，Int. J. Mol. Sci. 2021, 22, 13170,
2. Yu-Shi Wang, Chen Chen, Shi-Yin Zhang, Yang Li and Ying-Hua Jin * (20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2，Int. J. Mol. Sci. 2021, 22, 9289
3. Wang YS, Li H, Li Y, Zhang S, Jin YH*, (20S)G-Rh2 inhibits NF-Kappa B regulated epithelial-mesenchymal transition by targeting Annexin A2. Biomolecules, 2020, 10, 528
4. Li H, Chen C, Li Y, Jin YH*, Specific interaction with human serum albumin reduces ginsenoside cytotoxicity in human umbilical vein endothelial cells, Frontiers in Pharmacology, doi.org/10.3389/ fphar.2020.00498
5. Yu-Shi Wang, Hongyan Zhu, He Li, Bing Zhao, Ying-Hua Jin*. Ginsenoside compound K inhibits NF-κB by targeting Annexin A2. J Ginseng Res, 2019，43，452-459
6. Yu-Shi Wang, He Li, Hongyan Zhu, Yang Li, Ying-Hua Jin* Identification of natural compounds targeting Annexin A2 with an anti-cancer effect Protein Cell， 2018, 9(6):568–579
7. Yu-Shi Wang, Yingjia Lin, He Li, Yang Li, Zhiguang Song，Ying-Hua Jin* The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity Scientific Reports 7, 12408 (2017) doi:10.1038/s41598-017-12572-4
8. Yingjia Lin, Yang Li, Zhi-Guang Song, Hongyan Zhu, Ying-Hua Jin* The interaction of serum albumin with ginsenoside Rh2 (G-Rh2) resulted in the downregulation of G-Rh2 cytotoxicity J Ginseng Res 2017，41，330-338
9. Yuan Shen, Shanshan Liu, Jiao Fan, Yinghua Jin,* , Baolei Tian, Xiaofei Zheng*, Hanjiang Fu*, Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC–p53 protein interactions EMBO Rep. 2017，18(4)，536-548 (IF:8.807, 被引6次)
10. Yang Li，Xiaokang Liu，Dan Jiang， Yingjia Lin，Yushi Wang，Qing Li，Ying-Hua Jin* Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells Arch. Pharm. Res. 2016，39(9)，1257-1265, 2016. 09
11. Shanshan Liu， Juanjuan Zhu， Taifeng Jiang， Yiran Zhong， Yi Tie，Yongge Wu， Xiaofei Zheng Yinghua Jin* & Hanjiang Fu* Identification of lncRNA MEG3 Binding Protein Using MS2-Tagged RNA Affinity Purification and Mass Spectrometry，Appl Biochem Biotechnol 2015, 176, 1834-1845
12. Yingjia Lin，Dan Jiang，Yang Li，Xinye Han，Di Yu，Jeong Hill Park，Ying-Hua Jin* Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells J Ginseng Res 2015，39，22-28 (IF:6.06, 被引93次)
13. Chun-Ying Liu, Rui-Xin Zhou, Chang-Kai Sun, Ying-Hua Jin, Hong-Shan Yu, Tian-Yang Zhang, Long-Quan Xu, Feng-Xie Jin. Preparation of minor ginsenosides C-Mc, C-Y, F2, and C-K fromAmerican ginseng PPD-ginsenoside using special ginsenosidase type-I from Aspergillus niger g.848. J Ginseng Res, 2015, 39:221-229
14. Xiao-Xi Guo, Yang Li, Chao Sun, Dan Jiang, Ying-Hua Jin* p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell 2014, 5, 224 – 234 （IF：14.87，被引53次）
15. Liu CY, Jin YH，Yu HS, Sun CK, Zhou SP, Zhu YH, Xu LQ, Yu C, Jin FX. Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain. J Ind Microbiol Biotechnol, 2014, 41, 887-892.
16. Liu CY, Jin YH, Yu HS, Sun CK, Gao P, Xiao YK, Zhang TY, Xu LQ, Im WT, Jin FX. Biotransformation pathway and kinetics of ginsenosidase type I hydrolyzing 3-O- and 20-O-multi- glucosides of PPD type ginsenosides. Process Biochem, 2014, 49, 813-820.
17. Chao Sun, Xiaoxi Guo, Ying-Hua Jin* Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15. Int. J. Mol. Sci. 2013, 14, 850-870
18. Xiaoxi Guo, Qiao Guo, Yang Li, Seung ki Lee*, Ying-Hua Jin*, Ginsenoside Rh2 induces human hepatoma cell apoptosis via Bax/Bak triggered cytochrome c release and caspase-9/-caspase-8 activation. Int. J. Mol. Sci. 2012, 13, 15523-15535 （被引47次）
19. Ying Liu, Guo-Yan Zhang, Yang Li, Ya-Nan Zhang, Sheng-Ji An*, Ying-Hua Jin* Synthesis of Novel Amide Derivatives with In Vitro Antiproliferative and Cytotoxic Activity Heteroatom Chemistry 2013, 24, 9-17
20. Zhuo Zhan, Kan He, Yang Li, Ying-Hua Jin* Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers Apoptosis via Interfering Bcl-xL. PLoS One. 2012, 7 (9) e44923.（被引 9次）
21. Chuan Xiao§, Chao Sun§, Weiwei Han, Feng Pan, Yu Li, Zhi-Guang Song, Ying-Hua Jin Synthesis of 6-(het) ary Xylocydine Analogues and Evaluating their Inhibitory Activities of CDK1 and CDK2 in Vitro. Bioorg & Medi Chem. 2011，19， 7100-7110
22. Xiaoxi Guo, Hanna Kim, Yang Li, Hyungshin Yim, Seung Ki Lee*, Ying-Hua Jin. Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis. Protein & Cell. 2011, 2, 543-553. （IF:14.87, 被引6次）
23. Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo Zhan, Chao Sun, and Ying-Hua Jin*, Cotreatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, Bax translocation, and cytochrome c release. Mol Carcinogen 2011， 50，760-769 （IF:4.856，被引71次）
24. Yang Li , Kan He, Yinghui Huang, Daxin Zheng, Chang Gao, Lin Cui, and Ying-Hua Jin*, Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells. Mol Carcinogen 2010, 49, 630-640. （IF:4.856, 被引120次）
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