研究成果： |
主持科研项目： 1.国家重点研发计划，2021YFC2301504，诱导HIV-1高效广谱中和抗体的免疫原设计，2021/12-2024/11，182.00万元，主持，在研 2.“十三五”国家科技重大专项增补课题，2018ZX10731101-001-020，可诱导广谱中和抗体的gp120蛋白三聚体研究，2019/01/01-2020/12/31，200.00万元，结题，主持 3.国家自然科学基金面上项目，81472816，衣壳蛋白基因修饰溶瘤腺病毒基因治疗载体的设计和治疗恶性肿瘤的研究，2015/01-2018/12，72万元，结题，主持 4.国家自然科学基金面上项目，31270807，钙离子介导的HIV-1 Vpu拮抗Tetherin作用机制的研究，2013/01-2016/12，80万元，结题，主持 5.“十二五”国家科技重大专项子课题，2013ZX10004608-003，艾滋病新型靶标病毒构建及比较医学研究关键技术创建，2013/01-2015/12，73.62万元，结题，主持 6.国家自然科学基金国际交流与合作项目，812111027、HIV-1Vpu与宿主细胞限制因子Tetherin的拮抗作用、2013/01-2013/12、30万元、结题、主持 7.“十二五”国家科技重大专项子课题，2012ZX10001-009-07，DNA疫苗质量标准和临床样品生产2012/01-2015/12，200万元，结题，主持 8.国家自然科学基金面上项目，30872396，六邻体嵌合型rAd5载体逃避机体预存免疫的机制，2009/01-2011/12，30万元，结题，主持 9.“十一五”国家科技重大专项子课题，2009ZX10004-307，新型艾滋病嵌合病毒构建及感染机制研究，2009/01-2010/12，115.7万元，结题，主持 10.“十一五”国家科技重大专项子课题，2008ZX10001-012-02，提高细胞免疫应答的新型腺病毒载体的研究，2008/01-2010/12，150万元，结题，主持 11.国家自然科学基金面上项目，30570363，HIV-1Vif-ECS复合物作用机制的研究，2006/01-2008/12，35万元，结题，主持 代表性期刊论文： 1. Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C*, Zhou T*, Yu X*, Gao F*. Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci (Weinh). 2022 Mar 23;e2200063. 2. Wenmo Liu, Xupu Wang, Xinyao Feng, Jiahao Yu, Xinyao Liu, Xinyuan Jia, Haihong Zhang, Hui Wu, Chu Wang, Jiaxin Wu, Bin Yu∗and Xianghui Yu∗. Oncolytic adenovirus-mediated intratumoral expression of TRAIL and CD40L enhances immunotherapy by modulating the tumor microenvironment in immunocompetent mouse models. Cancer Letters. 535 (2022) 215661. 3. Xinyao Feng, Fangshen Li, Liangliang Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Zhen-An Qiao, Bin Yu∗, Xianghui Yu∗. TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy. Acta Biomaterialia. 143 (2022) 392-405. 4. Huaiyu Wang, Pingchao Li, Mo Zhang, Jinpeng Bi, Yizi He, Fangshen Li, Rongzhen Yu, Feng Gao, Wei Kong, Bin Yu∗, Ling Chen∗, Xianghui Yu∗. Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques. Microbial Biotechnology. 2022, Mar 15. doi: 10.1111/1751-7915.14022. 5. Wang C, Meng L, Wang J, Zhang K, Duan S, Ren P, Wei Y, Fu X, Yu B, Wu J, Yu X∗. Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction. Virologica Sinica 2021, 36:981-996. 6. Liu C, Cong X, Wang Y, Guo Q, Xie Y, Geng F, Guo J, Dong L, Zhou Y, Wu H, Yu B, Wu J, Zhang H∗, Yu X∗, Kong W. Fast DNA Vaccination Strategy Elicits a Stronger Immune Response Dependent on CD8(+)CD11c(+) Cell Accumulation. Frontiers in oncology 2021, 11:752444. 7. Duan S; Wang S; Song Y; Gao N; Meng L; Gai Y; Zhang Y; Wang S; Wang C; Yu B; Wu J; Yu X*, A novel HIV-1 inhibitor that blocks viral replication and rescues APOBEC3s by interrupting vif/CBFβ interaction. J Biol Chem. 2020, 295:14592-14605 8. Zixuan Wang, Wenmo Liu, Lizheng Wang, Peng Gao, Zhe Li, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu∗, Xianghui Yu∗. Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia. Signal Transduction and Targeted Therapy. 2020, 5(1):40. 9. Chu Wang, Kaikai Zhang, Lina Meng, Xin Zhang, Yanan Song, Ying Zhang, Yanxin Gai, Yuepeng Zhang, Bin Yu, Jiaxin Wu, Song Wang, Xianghui Yu*. The C-terminal Domain of Feline and Bovine SAMHD1 Proteins Has a Crucial Role in Lentiviral Restriction. J Biol Chem. 2020, 295(13):4252-4264. 10. Jinpeng Bi, Fangshen Li, Mo Zhang, Huaiyu Wang, Jingcai Lu, Yong Zhang, Hong Ling, Jiaye Wang, Feng Gao, Wei Kong, Bin Yu∗, Xianghui Yu∗. An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses. Immunology Letters. 2020, 222:29-39. 11. Lizheng Wang, Wenmo Liu, Zhe Li, Xupu Wang, Xinyao Feng, Zixuan Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu∗, Xianghui Yu∗. A tropism-transformed Oncolytic Adenovirus with Dual Capsid Modifications for enhanced Glioblastoma Therapy. Journal of Cancer. 2020, 11(19):5713-5726. 12. Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X*, Wu H*, Kong W*. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. J Neuroinflammation. 2020 17(1):72 13. Fei Geng, Xin Bao, Ling Dong, Qianqian Guo, Jie Guo, Yu Xie, Yi Zhou, Bin Yu, Hui Wu, Jiaxin Wu, Haihong Zhang*, Xianghui Yu*, Wei Kong. Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model. OncoImmunology. 2020, 9(1):1747350. 14. Meng Qu#, Weiran Wang#, Weiting Li, Jiaming Cao, Xin Zhang, Chu Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Hui Wu, Wei Kong, Xianghui Yu*. Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag. Front Microbiol. 2020 Jun 11;11:1230. 15. Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Xin Zhang, Wei Wang, Chuan Qin, Xianghui Yu* and Feng Gao*. Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques. Viruses. 12(2) pii: E163 (2020). 16. Chu Wang#, Nan Gao#, Yanan Song, Sizhu Duan, Wei Wang, Zhe Cong, Chuan Qin, Chunlai Jiang, Xianghui Yu*, Feng Gao*. Reduction of peak viremia by an integration-defective SIV proviral DNA vaccine in rhesus macaques. Microbiol Immunol. 2020, 64(1):52-62. 17. Yue Hu, Yayuan Zheng, Mingrui Dai, Xueju Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Yinqiu Cui, Wei Kong, Hui Wu*, Xianghui Yu*, G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Science, 2019, 110(11):3442-3452. 18. Yue Hu, Yayuan Zheng, Mingrui Dai, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu*, Xianghui Yu*, Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs. Cell Adhesion and Migration. 2019, 13(1):285-292. 19. Yue Hu, Mingrui Dai, Yayuan Zheng, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu*, Xianghui Yu*, Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clinical epigenetics, 2018, 10(1):154. 20. Nan Gao#, Wei Wang#, Chu Wang#, Tiejun Gu, Rui Guo, Bin Yu, Wei Kong, Chuan Qin, Elena E Giorgi, Zhiwei Chen, Samantha Townsley, Shiu-Lok Hu, Xianghui Yu*, Feng Gao*. Development of broad neutralization activity in simian/human immunodeficiency virus-infected rhesus macaques after long-term infection, AIDS, 2018; 32(5): 555-563. 21. Di Liu, Lin Liu, Lizheng Wang, Sizhu Duan, Yanan Song, Meng Qu, Nan Gao, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic effects of mesenchymal stem cells combined with short hairpin RNA on liver injury induced by hepatitis B virus infection, Mol Med Rep. 2018; 17(1): 1731-1741. 22. Weiran Wang, Meng Qu, Jiawen Wang, Xin Zhang, Haihong Zhang, Jiaxin Wu, Bin Yu, Hui Wu, Wei Kong*, Xianghui Yu*, Autoubiquitination of feline E3 ubiquitin ligase BCA2. Gene, 2018, 638:1-6. 23. Lizheng Wang, Zixuan Wang, Rui Zhu, Jinpeng Bi, Xinyao Feng, Wenmo Liu, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression, PLoS One, 2017, 12(6):e0179476. 24. Chu Wang, Chunlai Jiang, Nan Gao, Kaikai Zhang, Donglai Liu, Wei Wang, Zhe Cong, Chuan Qin, Vitaly V. Ganusov, Guido Ferrari, Celia LaBranche, David C. Montefiori, Wei Kong, Xianghui Yu *, Feng Gao*, Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine, Viruses. 2017, 9(6): 135. 25. Lu Fu, Yingnan Li, Yue Hu, Yayuan Zheng, Bin Yu, Haihong Zhang, Jiaxin Wu, Hui Wu*, Xianghui Yu*, Wei Kong*, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 7: 41041. 获得学术奖励: 1.于湘晖（1/7）；恶性肿瘤的发病机制和生物治疗研究，吉林省科学技术奖，二等奖，2021（于湘晖，于彬，张海红，孔维，詹杨，吴慧，吴嘉昕) 2.于湘晖（4/5），艾滋病病毒与宿主天然防御因子相互作用新机制的研究，国家自然科学奖，二等奖，2017（于晓方，张文艳，杜娟，于湘晖，赵可） 3.于湘晖（1/10），艾滋病病毒辅助蛋白与宿主限制因子相互作用研究，吉林省自然科学学术成果奖评审委员会，吉林省自然科学学术成果奖，一等奖，2014（于湘晖，孔维，吴嘉昕，张海红，吴慧，于彬，王晓丹，左陶，吕铭宇，王佳雯） 5.于湘晖（2/10），HIV感染机制和人体对HIV免疫保护机制的研究，吉林省科技厅，吉林省科学技术奖，一等奖，2013（孔维，于湘晖，姜春来，吴永革，陈妍，单亚明，张喜珍，张海红，于彬，吴嘉昕） 6.于湘晖（2/10），腺病毒载体的预存免疫及解决策略的相关研究，吉林省自然科学学术成果奖评审委员会，吉林省自然科学学术成果奖，二等奖，2013（孔维，于湘晖，吴永革，姜春来，于彬，张喜珍，张海红，吴嘉昕，陈妍） 7.于湘晖（3/5），宫颈癌HPV感染、病毒基因突变以及DNA疫苗的非病毒载体构建，中国抗癌协会，中国抗癌协会科技奖，三等奖，2009（查晓，孔维，于湘晖，张国楠，乌恩齐） |
