研究成果 |
首次发现真性红细胞增多症患者体内存在酪氨酸激酶JAK2V617F突变，最先应用JAK2V617F转基因小鼠模型证明了JAK2V617F是导致骨髓增殖性肿瘤的原因。以蛋白质酪氨酸激酶和磷酸酶为靶标，先后从天然产物、有机和无机金属配合物中筛选到20余种极具临床应用前景的治疗2型糖尿病、癌症、免疫缺陷等人类重大疾病的抑制剂。 主持和参与各类科研课题20余项，发表SCI收录的论文50余篇，获得吉林省自然科学奖一等奖1次（2015年，第二完成人）、吉林省科技进步奖一等奖1次（2010，第三完成人）、中华医学科技奖三等奖1次（2014年，第二完成人）。 代表性论文（近5年）： 1. Cui H, Yang L, Fu X, Li G, Xing S*, Wang X*. Ti3C2 MXene-based aptasensor for sensitive and simultaneous detection of two diabetes biomarkers. Surf Interfaces. 2023 October, (41) :103196. 2. Fu Y, Sui Y, Zhao Y, Jiang J, Wang X, Cui J, Fu X, Xing S*, Zhao ZJ*. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion. Aging (Albany NY). 2023 Jun 6;15(11): 4949. 3. Sui Y, Li S, Fu X, Zhao ZJ*, Xing S*. Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease. J Transl Med. 2023 Feb 10; 21(1): 109. 4. Lu J, Wang C, Ma Y, Liu K, Fu X, Xing S*. Exploration of the Product Specificity of chitosanase CsnMY002 and Mutants Using Molecular Dynamics Simulations. Molecules. 2023 Jan 20; 28(3): 1048. 5. Cui H, Fu X, Yang L, Xing S*, Wang X*. 2D Titanium Carbide Nanosheets Based Fluorescent Aptasensor for Sensitive Detection of Thrombin. Talanta. 2021, 228: 122219. 6. Chen X, Fu X, Zhao W, Ho WT, Xing S*, Zhao ZJ*. Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells. Signal Transduct Target Ther. 2020, 5(1): 83-85. 7. Yuan C, Wang W, Wang J, Li X, Wu YB, Li S, Lu L*, Zhu M*, Xing S*, Fu X. Potent and selective PTP1B inhibition by a platinum(ii) complex: possible implications for a new antitumor strategy. Chem Commun (Camb). 2019, 56(1): 102-105. 8. Lin L, Lu L*, Du R, Yuan C, Zhu M*, Fu X, Xing S*. A Ce(iii) complex potently inhibits the activity and expression of tyrosine phosphatase SHP-2. Dalton Trans. 2019, 48(47): 17673-17682. |
